Folic acid, also known as vitamin B9, is a water-soluble vitamin from the B-complex that plays a crucial role in cell division, DNA synthesis, blood formation, and tissue growth. In its natural form - the form found in foods - it is called folate, while folic acid is the synthetic, particularly stable form used in dietary supplements and fortified foods.
The name is derived from the Latin word folium (leaf), as folate was first discovered in green leafy vegetables. Good natural sources include spinach, broccoli, kale, asparagus, legumes, oranges, whole-grain products, and liver.
Folic acid is essential for growth, new cell formation, and the development of the nervous system - particularly during pregnancy, as it supports neural tube formation in the unborn child. A deficiency can have serious consequences, which is why folic acid is considered one of the most important vitamins of all.
After absorption, folic acid is converted into the active form tetrahydrofolate (THF), which acts as a coenzyme in a wide range of vital processes.
Cell division and DNA synthesis:
Folate is necessary for the formation of nucleic acids (DNA and RNA) - the genetic building blocks of every cell. Without sufficient folic acid, the body cannot produce new cells, which is particularly critical during periods of rapid growth - such as pregnancy, childhood, or tissue regeneration.
Blood formation:
Together with vitamin B12, folic acid is crucial for the maturation of red blood cells. A deficiency leads to so-called megaloblastic anemia, in which large, dysfunctional blood cells develop, causing fatigue, paleness, and concentration problems.
Protection of the nervous system and homocysteine breakdown:
Together with vitamins B6 and B12, folic acid lowers the level of the amino acid homocysteine, which, in excess, damages blood vessel walls and promotes cardiovascular disease. In this way, it indirectly contributes to heart health and vascular elasticity.
Pregnancy and development:
A sufficient intake of folic acid is crucial during pregnancy for the development of the embryo. It reduces the risk of serious malformations such as neural tube defects (e.g., spina bifida) by up to 70%. Therefore, women who wish to have children are advised to take 400 µg of folic acid daily, starting before conception.
Skin, hair, and tissue:
Because folic acid promotes cell division and regeneration, it also has a positive effect on skin renewal, hair growth, and wound healing.
Supports cell division and the growth of new cells
Promotes DNA and RNA synthesis
Supports the formation of red blood cells and helps prevent anemia
Protects the heart and blood vessels through homocysteine regulation
Essential for a healthy pregnancy and the development of the nervous system in the fetus
Supports skin, hair, and tissue regeneration
Promotes mental performance and concentration
Folic acid is generally very well tolerated. Since it is water-soluble, excess amounts are excreted in the urine. However, at very high doses (over 1000 µg per day), folic acid can mask a vitamin B12 deficiency, as it corrects the anemia but does not prevent neurological damage. Therefore, at higher doses, combined intake with vitamin B12 is recommended.
A folic acid deficiency can be caused by an unbalanced diet, alcohol, stress, certain medications (e.g., birth control pills, methotrexate, antiepileptic drugs), or increased rates of cell division.
Folic acid is an essential vitamin for growth, blood formation, and cellular health. It ensures smooth cell division, protects the cardiovascular system, and is indispensable for a healthy pregnancy. Since it is often insufficiently provided by many modern diets, women of childbearing age, older people, and individuals experiencing high levels of stress can particularly benefit from targeted folic acid intake - ideally in combination with vitamins B12 and B6 for a comprehensive effect on cells, blood, and nerves.
Bailey LB, Gregory JF. (1999): Folate metabolism and requirements. J Nutr, 129(4), 779–782.
Lucock M. (2000): Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab, 71(1–2), 121–138.
Blom HJ, Shaw GM, den Heijer M, Finnell RH. (2006): Neural tube defects and folate: case far from closed. Nat Rev Neurosci, 7(9), 724–731.
Selhub J. (2002): Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging, 6(1), 39–42.
